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Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations
Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity and DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanisms to human germline mutation remain unknown. Here, we s...
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| Publicat a: | Nat Genet |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317876/ https://ncbi.nlm.nih.gov/pubmed/30510240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0285-7 |
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