Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity and DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanisms to human germline mutation remain unknown. Here, we s...

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Udgivet i:Nat Genet
Main Authors: Seplyarskiy, Vladimir B., Akkuratov, Evgeny E., Akkuratova, Natalia, Andrianova, Maria A., Nikolaev, Sergey I., Bazykin, Georgii A., Adameyko, Igor, Sunyaev, Shamil R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317876/
https://ncbi.nlm.nih.gov/pubmed/30510240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0285-7
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