SPOP E3 Ubiquitin Ligase Adaptor Epigenetically Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.

The SPOP gene, encoding an E3 ubiquitin ligase adaptor, is frequently mutated in a number of cancer types such as prostate. However, the mechanisms by which SPOP functions as a tumor suppressor remain poorly understood. Here we show that SPOP promotes senescence, an important tumor suppression mecha...

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Publicat a:Cell Rep
Autors principals: Zhu, Hengrui, Ren, Shancheng, Bitler, Benjamin G., Aird, Katherine M., Tu, Zhigang, Skordalakes, Emmanuel, Zhu, Yasheng, Yan, Jun, Sun, Yinghao, Zhang, Rugang
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644472/
https://ncbi.nlm.nih.gov/pubmed/26527005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.083
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