Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is a major cause of death among breast cancer patients that results from intrinsic and acquired resistance to systemic chemotherapies. To identify novel targets for effective treatment of TNBC through combination strategies with MEK inhibitor (AS703026), we used...

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Vydáno v:J Cancer
Hlavní autoři: Lee, Jangsoon, Galloway, Rachael, Grandjean, Geoff, Jacob, Justin, Humphries, Juliane, Bartholomeusz, Chandra, Goodstal, Samantha, Lim, Bora, Bartholomeusz, Geoffrey, Ueno, Naoto T., Rao, Arvind
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643087/
https://ncbi.nlm.nih.gov/pubmed/26640591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.13266
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