Histone deacetylase inhibitor enhances the efficacy of MEK inhibitor through NOXA-mediated MCL1 degradation in triple-negative and inflammatory breast cancer

PURPOSE: Inflammatory breast cancer (IBC), diagnosed clinically, and triple-negative breast cancer (TNBC), diagnosed by molecular receptor status, are the two most aggressive forms of breast cancer, and both lack effective targeted therapies. We previously demonstrated involvement of histone deacety...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Torres-Adorno, Angie M., Lee, Jangsoon, Kogawa, Takahiro, Ordentlich, Peter, Tripathy, Debu, Lim, Bora, Ueno, Naoto T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559319/
https://ncbi.nlm.nih.gov/pubmed/28465444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2622
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