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Design, Synthesis and Biological evaluation of Multifunctional Ligands Targeting Opioid and Bradykinin 2 Receptors
We report here the design and synthesis of novel multifunctional ligands that act as (μ/δ) opioid agonists and bradykinin 2 receptor antagonists. These multifunctional ligands were designed to interact with the multiple receptors to show an enhanced analgesic effect, with no opioid-induced tolerance...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642888/ https://ncbi.nlm.nih.gov/pubmed/26316468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.08.014 |
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