Design synthesis and structure–activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl) propionamide derivatives as opioid ligands

Here, we report the design, synthesis and structure activity relationship of novel small molecule opioid ligands based on 5-amino substituted (tetrahydronaphthalen-2-yl)methyl moiety with N-phenyl-N-(piperidin-2-yl)propionamide derivatives. We synthesized various molecules including amino, amide and...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Deekonda, Srinivas, Rankin, David, Davis, Peg, Lai, Josephine, Vanderah, Todd. W., Porecca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873254/
https://ncbi.nlm.nih.gov/pubmed/26712115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.11.030
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