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Design, synthesis, and biological evaluation of a series of bifunctional ligands of Opioids/SSRIs

A series of opioid and serotonin re-uptake inhibitors (SSRIs) bifunctional ligands have been designed, synthesized, and tested for their activities and efficacies at μ-, δ- and κ opioid receptors and SSRIs receptors. Most of the compounds showed high affinities for μ- and δ-opioid receptors and lowe...

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Foilsithe in:Bioorg Med Chem
Main Authors: Mehr-un-Nisa, Munawar, Munawar A., Lee, Yeon Sun, Rankin, David, Munir, Jawaria, Lai, Josephine, Khan, Misbahul A., Hruby, Victor J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349363/
https://ncbi.nlm.nih.gov/pubmed/25703306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.047
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