Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities

The optimization and truncation of our lead peptide-derived ligand TY005 possessing eight amino-acid residues was performed. Among the synthesized derivatives, NP30 (Tyr(1)-DAla(2)-Gly(3)-Phe(4)-Gly(5)-Trp(6)-O-[3′,5′-Bzl(CF(3))(2)]) showed balanced and potent opioid agonist as well as substance P a...

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Detalhes bibliográficos
Main Authors: Nair, Padma, Yamamoto, Takashi, Largent-Milnes, Tally M., Cowell, Scott, Kulkarni, Vinod, Moye, Sharif, Navratilova, Edita, Davis, Peg, Ma, Shou-Wu, Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810412/
https://ncbi.nlm.nih.gov/pubmed/23899615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.065
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