A Structure–Activity Relationship Study and Combinatorial Synthetic Approach of C-Terminal Modified Bifunctional Peptides That Are δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

A series of bifunctional peptides with opioid agonist and substance P antagonist bioactivities were designed with the concept of overlapping pharmacophores. In this concept, the bifunctional peptides were expected to interact with each receptor separately in the spinal dorsal horn where both the opi...

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Autors principals: Yamamoto, Takashi, Nair, Padma, Vagner, Josef, Largent-Milnes, Tally, Davis, Peg, Ma, Shou-wu, Navratilova, Edita, Moye, Sharif, Tumati, Suneeta, Lai, Josephine, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737825/
https://ncbi.nlm.nih.gov/pubmed/18266313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070332f
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