Improving Metabolic Stability By Glycosylation: Bifunctional Peptide Derivatives That Are Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

In order to obtain a metabolically more stable analgesic peptide derivative, O-β-glycosylated serine (Ser(Glc)) was introduced into TY027 (Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-3’,5’-Bzl(CF(3))(2)) which was a previously reported bifunctional compound with delta/mu opioid agonist and neurokinin-1 rec...

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Główni autorzy: Yamamoto, Takashi, Nair, Padma, Jacobsen, Neil E., Vagner, Josef, Kulkarni, Vinod, Davis, Peg, Ma, Shou-wu, Navratilova, Edita, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format: Artigo
Język:Inglês
Wydane: 2009
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521585/
https://ncbi.nlm.nih.gov/pubmed/20560643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900473p
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