Biological and Conformational Evaluation of Bifunctional Compounds for Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists Possessing Two Penicillamines

Neuropathic pain states and tolerance to opioids can result from system changes in the CNS, such as up-regulation of the NK1 receptor and substance P, which have anti-opioid effects in ascending or descending pain-signaling pathways. Bifunctional compounds, possessing both the NK1 antagonist pharmac...

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Detalhes bibliográficos
Main Authors: Yamamoto, Takashi, Nair, Padma, Jacobsen, Neil E., Kulkarni, Vinod, Davis, Peg, Ma, Shou-wu, Navratilova, Edita, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943425/
https://ncbi.nlm.nih.gov/pubmed/20617791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100157m
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