Dual PI3K/mTOR inhibitor BEZ235 exerts extensive antitumor activity in HER2-positive gastric cancer

BACKGROUND: To investigate the in vitro and in vivo antitumor activity of dual PI3K/mTOR inhibitor BEZ235 (NVP-BEZ235) in HER2-positive gastric cancer. METHODS: HER2-positive breast cancer cell line (BT474), HER2-positive (NCI-N87 and SNU216), and HER2-negative (MKN45) gastric cancer cell lines were...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Zhu, Yan, Tian, Tiantian, Zou, Jianling, Wang, Qiwei, Li, Zhongwu, Li, Yanyan, Liu, Xijuan, Dong, Bin, Li, Na, Gao, Jing, Shen, Lin
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641417/
https://ncbi.nlm.nih.gov/pubmed/26560145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1900-y
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