NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells

The PI3K/Akt/mTOR pathway is a prototypic survival pathway and constitutively activated in many malignant conditions. Moreover, activation of the PI3K/Akt/mTOR pathway confers resistance to various cancer therapies and is often associated with a poor prognosis. In this study, we explored the antitum...

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Autors principals: MOON, DU G., LEE, SANG E., OH, MI M., LEE, SANG C., JEONG, SEONG J., HONG, SUNG K., YOON, CHEOL Y., BYUN, SEOK S., PARK, HONG S., CHEON, JUN
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121414/
https://ncbi.nlm.nih.gov/pubmed/24969552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2505
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