Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway

Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to the lack of proper models, mechanisms underlying PTX resistance in GC were not well studied. Using established PTX-resistant GC cell sublines HGC-27R, we for the first time i...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Chen, Dongshao, Lin, Xiaoting, Zhang, Cheng, Liu, Zhentao, Chen, Zuhua, Li, Zhongwu, Wang, Jingyuan, Li, Beifang, Hu, Yanting, Dong, Bin, Shen, Lin, Ji, Jiafu, Gao, Jing, Zhang, Xiaotian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833539/
https://ncbi.nlm.nih.gov/pubmed/29374144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0132-2
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