Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway

Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to the lack of proper models, mechanisms underlying PTX resistance in GC were not well studied. Using established PTX-resistant GC cell sublines HGC-27R, we for the first time i...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Chen, Dongshao, Lin, Xiaoting, Zhang, Cheng, Liu, Zhentao, Chen, Zuhua, Li, Zhongwu, Wang, Jingyuan, Li, Beifang, Hu, Yanting, Dong, Bin, Shen, Lin, Ji, Jiafu, Gao, Jing, Zhang, Xiaotian
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833539/
https://ncbi.nlm.nih.gov/pubmed/29374144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0132-2
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