Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation of striated muscle thin filament assembly; its physiological function has yet to be studied. We found that knockout of Lmod2 in mice results in abnormally short thin filaments in the heart. We also discovered...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pappas, Christopher T., Mayfield, Rachel M., Henderson, Christine, Jamilpour, Nima, Cover, Cathleen, Hernandez, Zachary, Hutchinson, Kirk R., Chu, Miensheng, Nam, Ki-Hwan, Valdez, Jose M., Wong, Pak Kin, Granzier, Henk L., Gregorio, Carol C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640780/
https://ncbi.nlm.nih.gov/pubmed/26487682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508273112
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