Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation of striated muscle thin filament assembly; its physiological function has yet to be studied. We found that knockout of Lmod2 in mice results in abnormally short thin filaments in the heart. We also discovered...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pappas, Christopher T., Mayfield, Rachel M., Henderson, Christine, Jamilpour, Nima, Cover, Cathleen, Hernandez, Zachary, Hutchinson, Kirk R., Chu, Miensheng, Nam, Ki-Hwan, Valdez, Jose M., Wong, Pak Kin, Granzier, Henk L., Gregorio, Carol C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640780/
https://ncbi.nlm.nih.gov/pubmed/26487682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508273112
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker