Single-stranded DNA cleavage by divergent CRISPR-Cas9 enzymes

Double-stranded DNA (dsDNA) cleavage by Cas9 is a hallmark of type II CRISPR-Cas immune systems. Cas9–guide RNA complexes recognize 20-base-pair sequences in DNA and generate a site-specific double-strand break, a robust activity harnessed for genome editing. DNA recognition by all studied Cas9 enzy...

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Udgivet i:Mol Cell
Main Authors: Ma, Enbo, Harrington, Lucas B., O’Connell, Mitchell R., Zhou, Kaihong, Doudna, Jennifer A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636735/
https://ncbi.nlm.nih.gov/pubmed/26545076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.030
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