Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective Inhibitor of Nuclear Export (SINE) compounds results in reversal of EMT in snail-transduced primary human mammary epithelial...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Azmi, Asfar S., Muqbil, Irfana, Wu, Jack, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Bollig-Fischer, Aliccia, Dyson, Gregory, Kauffman, Michael, Landesman, Yosef, Shacham, Sharon, Philip, Philip A., Mohammad, Ramzi M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633607/
https://ncbi.nlm.nih.gov/pubmed/26536918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16077
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items