P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. Although previous studies have reported transcriptional upregulation of nSMase2 in response to daunorubicin, through Sp1 and Sp3 transcription factors, the...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Shamseddine, A A, Clarke, C J, Carroll, B, Airola, M V, Mohammed, S, Rella, A, Obeid, L M, Hannun, Y A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632297/
https://ncbi.nlm.nih.gov/pubmed/26512957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.268
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