P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. Although previous studies have reported transcriptional upregulation of nSMase2 in response to daunorubicin, through Sp1 and Sp3 transcription factors, the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Shamseddine, A A, Clarke, C J, Carroll, B, Airola, M V, Mohammed, S, Rella, A, Obeid, L M, Hannun, Y A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632297/
https://ncbi.nlm.nih.gov/pubmed/26512957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.268
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares