P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. Although previous studies have reported transcriptional upregulation of nSMase2 in response to daunorubicin, through Sp1 and Sp3 transcription factors, the...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Shamseddine, A A, Clarke, C J, Carroll, B, Airola, M V, Mohammed, S, Rella, A, Obeid, L M, Hannun, Y A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632297/
https://ncbi.nlm.nih.gov/pubmed/26512957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.268
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