Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase

All-trans-retinoic acid (ATRA) induces growth arrest of many cell types. Previous studies have reported that ATRA can modulate cellular sphingolipids, but the role of sphingolipids in the ATRA response is not clear. Using MCF-7 cells as a model system, we show that ATRA stimulates an increase in cer...

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Detalhes bibliográficos
Main Authors: Clarke, Christopher J., Mediwala, Krutika, Jenkins, Russell W., Sutton, Che A., Tholanikunnel, Baby G., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122215/
https://ncbi.nlm.nih.gov/pubmed/21536668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193375
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