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Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. I...

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Detalhes bibliográficos
Main Authors: Wu, Bill X., Clarke, Christopher J., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405913/
https://ncbi.nlm.nih.gov/pubmed/20552297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-010-8120-z
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