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Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. I...

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Bibliografiske detaljer
Main Authors: Wu, Bill X., Clarke, Christopher J., Hannun, Yusuf A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405913/
https://ncbi.nlm.nih.gov/pubmed/20552297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-010-8120-z
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