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Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. I...

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Autori principali: Wu, Bill X., Clarke, Christopher J., Hannun, Yusuf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405913/
https://ncbi.nlm.nih.gov/pubmed/20552297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-010-8120-z
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