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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms (nSMase1, nSMase2 and nSMase3) are responsible for this activity. In MCF-7 cells, we...

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Detalhes bibliográficos
Main Authors: Clarke, Christopher J., Cloessner, Emily A., Roddy, Patrick L., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715995/
https://ncbi.nlm.nih.gov/pubmed/21303347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101752
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