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Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-α Involves Protein Kinase C-δ in Lung Epithelial Cells()

Neutral sphingomyelinases (N-SMases) are major candidates for stress-induced ceramide production, but there is still limited knowledge of the regulatory mechanisms of the cloned N-SMase enzyme—nSMase2. We have reported that p38 mitogen-activated protein kinase (MAPK) was upstream of nSMase2 in tumor...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Clarke, Christopher J., Guthrie, J. Michael, Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698891/
https://ncbi.nlm.nih.gov/pubmed/18653803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.046250
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