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Analysis of membrane topology of neutral sphingomyelinase 2

Neutral sphingomyelinase 2 (nSMase2), which has two hydrophobic segments at its NH(2)-terminus, plays important roles in ceramide-mediated cell regulation. Here, we investigated the membrane topology of nSMase2. When a double-tagged nSMase2 at both the NH(2) and COOH termini, was overexpressed in MC...

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Detalhes bibliográficos
Main Authors: Tani, Motohiro, Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868537/
https://ncbi.nlm.nih.gov/pubmed/17349629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.02.046
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