PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues, as new agents are being clinically evaluated. PI...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncogenesis
Egile Nagusiak: Payne, S N, Maher, M E, Tran, N H, Van De Hey, D R, Foley, T M, Yueh, A E, Leystra, A A, Pasch, C A, Jeffrey, J J, Clipson, L, Matkowskyj, K A, Deming, D A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632089/
https://ncbi.nlm.nih.gov/pubmed/26436951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.28
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