PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues, as new agents are being clinically evaluated. PI...

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發表在:Oncogenesis
Main Authors: Payne, S N, Maher, M E, Tran, N H, Van De Hey, D R, Foley, T M, Yueh, A E, Leystra, A A, Pasch, C A, Jeffrey, J J, Clipson, L, Matkowskyj, K A, Deming, D A
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632089/
https://ncbi.nlm.nih.gov/pubmed/26436951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.28
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