PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues, as new agents are being clinically evaluated. PI...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Payne, S N, Maher, M E, Tran, N H, Van De Hey, D R, Foley, T M, Yueh, A E, Leystra, A A, Pasch, C A, Jeffrey, J J, Clipson, L, Matkowskyj, K A, Deming, D A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632089/
https://ncbi.nlm.nih.gov/pubmed/26436951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.28
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