PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and apoptosis. Interest in targeting the PI3K signaling cascade continues, as new agents are being clinically evaluated. PI...

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Detalles Bibliográficos
Publicado en:Oncogenesis
Main Authors: Payne, S N, Maher, M E, Tran, N H, Van De Hey, D R, Foley, T M, Yueh, A E, Leystra, A A, Pasch, C A, Jeffrey, J J, Clipson, L, Matkowskyj, K A, Deming, D A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632089/
https://ncbi.nlm.nih.gov/pubmed/26436951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2015.28
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