A CT-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer’s disease and affects SNCA expression

INTRODUCTION: We recently showed that tagging-SNPs across the SNCA locus were significantly associated with increased risk for LB pathology in AD cases. However, the actual genetic variant(s) that underlie the observed associations remain elusive. METHODS: We used a bioinformatics algorithm to catal...

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Publicado en:Alzheimers Dement
Main Authors: Lutz, Michael W., Saul, Robert, Linnertz, Colton, Glenn, Omolara-Chinue, Roses, Allen D., Chiba-Falek, Ornit
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630109/
https://ncbi.nlm.nih.gov/pubmed/26079410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.05.011
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