The Landscape of SNCA Transcripts Across Synucleinopathies: New Insights From Long Reads Sequencing Analysis

Dysregulation of alpha-synuclein expression has been implicated in the pathogenesis of synucleinopathies, in particular Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Previous studies have shown that the alternatively spliced isoforms of the SNCA gene are differentially expressed in d...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Tseng, Elizabeth, Rowell, William J., Glenn, Omolara-Chinue, Hon, Ting, Barrera, Julio, Kujawa, Steve, Chiba-Falek, Ornit
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629766/
https://ncbi.nlm.nih.gov/pubmed/31338105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00584
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