Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168

The SNCA intronic single nucleotide polymorphism (SNP), rs356168, has been associated with Parkinson’s disease (PD) in large genome wide association studies (GWAS). Recently, the PD-risk allele, rs356168-G was shown to increase SNCA-mRNA expression using genome edited human induced pluripotent stem...

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Bibliographische Detailangaben
Veröffentlicht in:Front Genet
Hauptverfasser: Glenn, Omolara-Chinue, Tagliafierro, Lidia, Beach, Thomas G., Woltjer, Randy L., Chiba-Falek, Ornit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611418/
https://ncbi.nlm.nih.gov/pubmed/28979294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00133
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