The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease

The molecular genetic basis that leads to Lewy Body (LB) pathology in 15–20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA) and Leucine-rich repeat kinase2 (LRRK2) have been implicated in the pathogenesis of Parkinson's disease (PD), the prototype of LB spectrum...

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Main Authors: Linnertz, Colton, Lutz, Michael W., Ervin, John F., Allen, Jawara, Miller, Natalie R., Welsh-Bohmer, Kathleen A., Roses, Allen D., Chiba-Falek, Ornit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140463/
https://ncbi.nlm.nih.gov/pubmed/24777780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu196
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