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The Alzheimer’s associated 5′ region of the SORL1 gene cis-regulates SORL1 transcripts expression

SORL1 has been identified as a major contributor to Late-Onset Alzheimer’s disease (LOAD). We test whether genetic variability in the 5′of SORL1 gene modulates the risk to develop LOAD via regulation of SORL1-mRNA expression and splicing. Two brain structures, differentially vulnerable to LOAD patho...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McCarthy, Jeanette J., Saith, Sunita, Linnertz, Colton, Burke, James R., Hulette, Christine M., Welsh-Bohmer, Kathleen A., Chiba-Falek, Ornit
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117021/
https://ncbi.nlm.nih.gov/pubmed/21185108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2010.10.004
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