Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

TAR DNA-binding protein 43 (TDP-43) is normally a nuclear RNA-binding protein that exhibits a range of functions including regulation of alternative splicing, RNA trafficking, and RNA stability. However, in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Amlie-Wolf, Alexandre, Ryvkin, Paul, Tong, Rui, Dragomir, Isabelle, Suh, EunRan, Xu, Yan, Van Deerlin, Vivianna M., Gregory, Brian D., Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y., Wang, Li-San, Lee, Edward B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624943/
https://ncbi.nlm.nih.gov/pubmed/26510133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141836
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