TDP-43 promotes neurodegeneration by impairing chromatin remodeling

Regulation of chromatin structure is critical for brain development and function. However, the involvement of chromatin dynamics in neurodegeneration is less well understood. Here we find, launching from Drosophila models of amyotrophic lateral sclerosis and frontotemporal dementia, that TDP-43 impa...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Berson, Amit, Sartoris, Ashley, Nativio, Raffaella, Van Deerlin, Vivianna, Toledo, Jon B., Porta, Sílvia, Liu, Shichong, Chung, Chia-Yu, Garcia, Benjamin A., Lee, Virginia M.-Y., Trojanowski, John Q., Johnson, F. Brad, Berger, Shelley L., Bonini, Nancy M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720388/
https://ncbi.nlm.nih.gov/pubmed/29153328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.10.024
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