TDP-43 promotes neurodegeneration by impairing chromatin remodeling

Regulation of chromatin structure is critical for brain development and function. However, the involvement of chromatin dynamics in neurodegeneration is less well understood. Here we find, launching from Drosophila models of amyotrophic lateral sclerosis and frontotemporal dementia, that TDP-43 impa...

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Bibliografski detalji
Izdano u:Curr Biol
Glavni autori: Berson, Amit, Sartoris, Ashley, Nativio, Raffaella, Van Deerlin, Vivianna, Toledo, Jon B., Porta, Sílvia, Liu, Shichong, Chung, Chia-Yu, Garcia, Benjamin A., Lee, Virginia M.-Y., Trojanowski, John Q., Johnson, F. Brad, Berger, Shelley L., Bonini, Nancy M.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720388/
https://ncbi.nlm.nih.gov/pubmed/29153328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.10.024
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