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TDP-43 skeins show properties of amyloid in a subset of ALS cases

Aggregation of TDP-43 proteins to form intracellular inclusions is the primary pathology in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with TDP-43 inclusions (FTLD-TDP). Histologically, in the cerebral cortex and limbic regions of affected ALS and FTLD-TDP patie...

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Main Authors: Robinson, John L., Geser, Felix, Stieber, Anna, Umoh, Mfon, Kwong, Linda K., Van Deerlin, Vivianna M., Lee, Virginia M.-Y., Trojanowski, John Q.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536927/
https://ncbi.nlm.nih.gov/pubmed/23124365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-1055-8
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