Effect of Cellular Location of Human Carboxylesterase 2 on CPT-11 Hydrolysis and Anticancer Activity

CPT-11 is an anticancer prodrug that is clinically used for the treatment of metastatic colorectal cancer. Hydrolysis of CPT-11 by human carboxylesterase 2 (CE2) generates SN-38, a topoisomerase I inhibitor that is the active anti-tumor agent. Expression of CE2 in cancer cells is under investigation...

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Vydáno v:PLoS One
Hlavní autoři: Hsieh, Yuan-Ting, Lin, Hsuan-Pei, Chen, Bing-Mae, Huang, Ping-Ting, Roffler, Steve R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624787/
https://ncbi.nlm.nih.gov/pubmed/26509550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141088
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