The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and β-glucuronidase in human colorectal tumours

AIMS: Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study was to determine, the reactivation of SN-38 fr...

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Main Authors: Tobin, Peter, Clarke, Stephen, Seale, J Paul, Lee, Soon, Solomon, Michael, Aulds, Sally, Crawford, Michael, Gallagher, James, Eyers, Tony, Rivory, Laurent
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2006
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885078/
https://ncbi.nlm.nih.gov/pubmed/16842384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02477.x
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