Secreted and tumour targeted human carboxylesterase for activation of irinotecan

Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer. CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. An approach to achieve tumour specific activation of CPT-11 is to transduce the cDNA encoding...

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Detalhes bibliográficos
Main Authors: Oosterhoff, D, Pinedo, H M, van der Meulen, I H, de Graaf, M, Sone, T, Kruyt, F A, van Beusechem, V W, Haisma, H J, Gerritsen, W R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364240/
https://ncbi.nlm.nih.gov/pubmed/12237777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600519
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