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Secreted and tumour targeted human carboxylesterase for activation of irinotecan
Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer. CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. An approach to achieve tumour specific activation of CPT-11 is to transduce the cDNA encoding...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364240/ https://ncbi.nlm.nih.gov/pubmed/12237777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600519 |
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