Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11

CPT-11 (irinotecan or 7-ethyl-10[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is an anticancer agent in use for the treatment of colon cancer. In order to be fully active, CPT-11 needs to be converted into SN-38 (7-ethyl-10-hydroxycamptothecin) by the enzyme carboxylesterase (CE). In huma...

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Detalhes bibliográficos
Main Authors: Oosterhoff, D, Overmeer, R M, de Graaf, M, van der Meulen, I H, Giaccone, G, van Beusechem, V W, Haisma, H J, Pinedo, H M, Gerritsen, W R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361903/
https://ncbi.nlm.nih.gov/pubmed/15756257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602362
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