The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and β-glucuronidase in human colorectal tumours

AIMS: Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study was to determine, the reactivation of SN-38 fr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tobin, Peter, Clarke, Stephen, Seale, J Paul, Lee, Soon, Solomon, Michael, Aulds, Sally, Crawford, Michael, Gallagher, James, Eyers, Tony, Rivory, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885078/
https://ncbi.nlm.nih.gov/pubmed/16842384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02477.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados