CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues

CPT-11 is a prodrug activated by carboxylesterases to the active metabolite SN-38 which is a potent inhibitor of topoisomerase I. CPT-11 is of clinical interest in the treatment of colorectal cancer. We evaluated the activities of CPT-11 converting carboxylesterase (CPT-CE) and topoisomerase I (topo...

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Detalhes bibliográficos
Main Authors: Guichard, S, Terret, C, Hennebelle, I, Lochon, I, Chevreau, P, Frétigny, E, Selves, J, Chatelut, E, Bugat, R, Canal, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362335/
https://ncbi.nlm.nih.gov/pubmed/10408839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690364
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