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CPT-11 converting carboxylesterase and topoisomerase I activities in tumour and normal colon and liver tissues
CPT-11 is a prodrug activated by carboxylesterases to the active metabolite SN-38 which is a potent inhibitor of topoisomerase I. CPT-11 is of clinical interest in the treatment of colorectal cancer. We evaluated the activities of CPT-11 converting carboxylesterase (CPT-CE) and topoisomerase I (topo...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362335/ https://ncbi.nlm.nih.gov/pubmed/10408839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690364 |
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