A carregar...
Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11
Several mammalian carboxylesterases were shown to activate the prodrug irinotecan (CPT-11) to produce SN-38, a topoisomerase inhibitor used in cancer therapy. However, the potential use of bacterial carboxylesterases, which have the advantage of high stability, has not been explored. We present the...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950602/ https://ncbi.nlm.nih.gov/pubmed/17239398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.067 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|