Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11

The activation of the anticancer prodrug CPT-11, to its active metabolite SN-38, is primarily mediated by carboxylesterases (CE). In humans, three CEs have been identified, of which human liver CE (hCE1; CES1) and human intestinal CE (hiCE; CES2) demonstrate significant ability to hydrolyze the drug...

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Detalhes bibliográficos
Main Authors: Hatfield, M. Jason, Tsurkan, Lyudmila, Garrett, Michael, Shaver, Timothy M., Hyatt, Janice L., Edwards, Carol C., Hicks, Latorya D., Potter, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991631/
https://ncbi.nlm.nih.gov/pubmed/20833148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.09.001
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